The Gaborski NanoBio Device Lab conducts applied research at the interface of nanomaterials and biology.
Please visit our Publications page for a list of recent journal articles.
We are researching the fabrication of ultrathin nano- and micro-porous membranes. These membranes are typically 1/1000th the thickness of a human hair with well controlled pore sizes. Part of our work focuses on the science behind manufacturing scale-up of nanomaterials, which typically have very low yields at extraordinary cost. The National Science Foundation has funded our laboratory’s efforts to develop nano manufacturing scale-up techniques to help integrate nanomembranes into miniaturized hemodialysis cartridges.
We are using ultrathin membranes to enable development of novel co-culture and barrier models as well as improved measurement and analysis of real-time barrier function. The ultrathin nature of the membranes not only enables improved physiological processes, but also optical, electrical and biochemical analysis of barrier properties. Furthermore, we can control and manipulate physical and biochemical cell-cell interactions by tuning membrane pore sizes and membrane thickness at the nanometer and micrometer scales. This work is currently funded by an NIH NIGMS R35 Early Investigator grant.
An ultrathin membrane is an ideal sieve due to the lack of internal voids and high permeability. We are using ultrathin nanoporous membranes to explore simplified purification methods of biomolecules that otherwise require complex and often low-yield processes. In combination with our goals of scalable nano manufacturing, these nano membranes may enable effective means of detecting and purifying contaminants from drinking water. In collaboration with our cellular microenvironment project, we are also exploring the purification of exosomes from mesenchymal stem cell media for therapeutic applications.